Wade has been treated the past few days for soreness in the knee, but has played throughout the Heat's historic winning streak, which moved to 26 consecutive games with Sunday's 109-77 victory against the Bobcats. They are within seven of tying the 1971-72 Los Angeles Lakers for the longest streak in NBA history.
"He got hit in the knee a couple of games back, and it's just sore and bruised," Miami coach Erik Spoelstra said of Wade before the game. "We are going to be proactive, and hopefully he will get some treatment and feel better tomorrow."
Wade has had problems with his knees in recent seasons. He underwent arthroscopic surgery last summer to repair damage in his left knee after dealing with pain throughout the Heat's run to an NBA title last season.
Wade is having the best shooting season of his career from the field, and is second on the team in scoring behind LeBron James, with averages of 21.7 points, 5.0 rebounds and 5.0 assists in 64 games.
Spoelstra has previously given veteran rotation players a couple of games off toward the end of the season as part of what he considers a "maintenance" program to help rest them before the playoffs.
It's likely that Wade is sitting out as more of a precaution, although Spoelstra has recently scoffed at the notion that he might start resting players with about three weeks remaining in the regular season.
The Bobcats, with the league's worst record now at 16-54, were the first opponent on a back-to-back set for the Heat, who travel Monday to face the Orlando Magic to start a four-game trip that also includes stops in Chicago, New Orleans and San Antonio.
Information from The Associated Press was used in this report.