Seabrook took a hit to the head from Canucks forward Raffi Torres in Game 3, and although he finished the game, the aftereffects kept him sidelined Tuesday.
"There's a chance he could have played, but he's not," Blackhawks coach Joel Quenneville said Thursday.
Torres received a minor interference penalty on the play, but the Blackhawks believed he should have been suspended for the hit to Seabrook's head. NHL senior executive vice president of hockey operations Colin Campbell said the hit did not merit a suspension.
On Thursday, Campbell defended himself against criticism of his decision.
"I've got a responsibility to try and protect players from other players in the game of hockey but yet keep the physicality in the game," Campbell said, according to The (Toronto) Globe and Mail. "To keep jobs like your jobs, everyone's jobs. The game supplies a lot of jobs.
"That's what's thankless about this job. You try to do the right thing, you try to keep physicality in the game and you guys think that I enjoy hearing everybody saying Torres should have been suspended. Well that would have been the easy thing to do. If they want to go forward and say that type of hit or all head hits should be suspended, maybe this job will be easier, but I don't think so."
John Scott took Seabrook's place on defense in Game 4, which the Blackhawks won 7-2 to stave off elimination. The Canucks lead the series 3-1.
ESPNChicago.com's Jesse Rogers contributed to this report.