McGuffie was given his release by coach Roch Rodriguez, thewolverine.com reported Friday.
McGuffie, a freshman from Texas, has been reported to be homesick and is expected to enroll in a school closer to home. If he goes to a Division I school he will have to sit out a year.
"I've talked to Sam before the [Thanksgiving] break and after the break," Rodriguez told The Detroit News last week. "We have several concerns. Sam has concerns at home, and we have concerns because he's had multiple concussions, three of them, so there's a lot of concerns there.
"I don't want to talk anything medically, because I'm not qualified, but it is something that the trainers and I have talked about and are concerned about. That's for his future, wherever he may be."