Mangino spent eight seasons as the coach at Kansas, winning national coach of the year honors in 2007 and leading the Jayhawks to a win in the Orange Bowl. But Mangino was fired following the 2009 season amid accusations of treating his players poorly.
Mangino was 50-48 at Kansas. He spent three seasons out of football before serving as the assistant head coach at Youngstown State last year.
"I am beyond thrilled to welcome Coach Mangino to the Cyclone football family," Iowa State coach Paul Rhoads said. "He has an imaginative offensive mind, an ability to play to his players' strengths, a track record of winning and a tremendous familiarity with the Big 12 Conference. In terms of calling plays and executing a game plan, he is top shelf."
Mangino got his collegiate coaching start at Youngstown State (1985-86), working for Jim Tressel. Three years later, he was hired by Bill Snyder at Kansas State and the Wildcats won at least nine games his final six seasons in Manhattan. Mangino joined Bob Stoops' first staff at Oklahoma in 1999, and was promoted to offensive coordinator the next year.
His eight-year tenure at Kansas included a remarkable renaissance. Inheriting a program with six consecutive losing seasons, Mangino turned a two-win team his first season into Orange Bowl champions five years later.
After Mangino went 12-1 at Kansas and won the Orange Bowl in 2007, he was given a big raise and contract extension through 2012 and honored as AP's national coach of the year.
Mangino resigned in 2009 amid allegations that he mistreated his players. He was defiant to the end, insisting after a last-second loss to Missouri in the season finale that he had done nothing wrong. He had four years left on his contract, worth $2.3 million per year, or a total of $9.2 million. He and the school reached a $3 million settlement.
Mangino replaces Courtney Messingham, who was fired after Iowa State finished in the bottom three of the Big 12 in points per game (24.8), yards per game (363), yards per play (4.82), rushing yards (143.83) and passing yards (219.17).