Jack Hoffman, the 8-year-old ESPY winner and famous Nebraska Cornhuskers football fan, again faces surgery or chemotherapy for a growing brain tumor.
Hoffman's father, Andy Hoffman, posted on the Caring Bridge website on Wednesday that Jack's doctors in Boston informed the family that his tumor, previously in remission, had grown since April.
"Today, we were humbly reminded that when your child has an inoperable brain tumor, that anything can happen at any point in time," Andy Hoffman wrote. "Despite Jack's tumor being declared in remission last October, today we learned that is no longer the case."
Former Nebraska running back Rex Burkhead, now a second-year running back for the Cincinnati Bengals, befriended Hoffman shortly after his cancer diagnosis in 2011. Hoffman, from Atkinson, Nebraska, gained notice nationally at the school's 2013 spring game, running for a 69-yard touchdown.
He won an ESPY in July 2013 for Best Moment.
Jack has endured two operations and one round of chemotherapy. His father told Huskers.com that Jack is "doing great."
"This is a mild setback," Andy Hoffman said, "and everyone remains optimistic for Jack, including and especially his mom and dad."
The Hoffmans remain scheduled to attend an NFL exhibition on Thursday night at Arrowhead Stadium as Burkhead and his Bengals visit Kansas City.