Anthony, the top backup at the position behind Joe Gore and Isaiah Battle, wants an opportunity to start elsewhere.
"I have enjoyed my time at Clemson and appreciate the opportunity I've had," Anthony said in a statement. "This is an outstanding program, but I wish to make a clean start at a program where I can hopefully be a starter. I want to thank all the Clemson coaches, my teammates and the Clemson family for their support. I will always be a Tiger."
Anthony played in 17 games over the last two seasons, making five starts. He had previously been suspended for the opener against Georgia for violating team rules.
"I appreciate the hard work Shaq has put into this program," coach Dabo Swinney said in a statement. "Sometimes a player needs a change. I support his decision and will help him any way I can. I wish him nothing but the best."