Oklahoma news outlets reported that the sign, held Saturday during ESPN's "College GameDay" in downtown Fort Worth, Texas, read: "Send 'em home #Trail-of-Tears #GoPokes."
The school's official Twitter account asked for the sign to be removed. Neither FSU nor the Seminole Nation immediately responded to requests for comment.
OSU does not condone the insensitive sign shown at today's GameDay event and have requested that it be removed.
- Oklahoma State Univ. (@okstate) August 30, 2014
The Trail of Tears refers to the relocation of Native Americans from the southeastern U.S. in the 19th century. The removal included members of the Cherokee, Muscogee, Seminole, Chickasaw and Choctaw nations, which are now based in Oklahoma.
Oklahoma State plays No. 1 FSU in Dallas on Saturday night.
The Associated Press contributed to this report.