An MRI confirmed the injury, but a surgery date has not been set.
Gurley injured his knee in the Bulldogs' 34-7 win over Auburn on Saturday night.
The former Heisman Trophy frontrunner was injured on a 6-yard run with a little more than five minutes remaining in the fourth quarter.
Saturday was Gurley's first game back for the Bulldogs after serving a four-game NCAA suspension for taking $3,000 for autographed memorabilia and other items over the course of two years.
Gurley rushed for 138 yards and a touchdown on 29 carries against the Tigers before leaving.
On the season, Gurley has rushed for 911 yards and nine touchdowns.
ESPN.com's Edward Aschoff contributed to this report.