Doctson injured the wrist Nov. 7 at Oklahoma State. He tried to play through it Saturday against Kansas, but had only one reception. Doctson, a former walk-on, has been one of the top receivers in college football this season, with 79 catches for 1,327 yards and 14 touchdowns.
"TCU football has been my hidden light to becoming a stronger individual on and off the field," Doctson wrote in a statement posted on Twitter. "... I was given a chance to play here and I made sure I played my heart out every time I tied the cleats! ...
"It might have been my last time putting on the purple and black but I smile because it happened ... I'll always be a Frog!"
On top of losing Doctson, 18th-ranked TCU could be without quarterback Trevone Boykin on Saturday at No. 7 Oklahoma. Patterson said that Boykin, who suffered an ankle injury against the Jayhawks, would be a game-time decision in Norman.
Earlier Wednesday, both Boykin and Doctson were named two of 15 semifinalists for the Walter Camp Player of the Year Award.
All-Big 12 center Joey Hunt is also questionable for Saturday with an undisclosed injury, Patterson said.