Dortch underwent surgery Saturday night.
The redshirt freshman is coming off a career game in which he torched Louisville for 10 catches, 167 yards and a school-record four touchdowns. Dortch ranks second in the ACC with 722 receiving yards this season.
He also has excelled in the return game, where he's worked as both a punt and a kick returner. Overall, he's racked up 1,290 all-purpose yards this season, the fifth-most in FBS.
With Dortch out, Wake Forest (5-3, 2-3 ACC) will turn to junior Tabari Hines to fill a similar role. Hines has 18 catches for 250 yards and 1 touchdown this season.
The Demon Deacons next travel to South Bend, Indiana on Saturday to take on fifth-ranked Notre Dame.