Wirfs, 19, started eight games as a true freshman in 2017 and was listed as the Hawkeyes' No. 1 right tackle to enter preseason camp, which opens this week. He was stopped by police early Sunday morning in Iowa City and booked into jail after he received a citation for operating while under the influence.
The sophomore from Mount Vernon, Iowa, was released later Sunday morning.
Wirfs' arrest comes eight days after Iowa defensive tackle Brady Reiff was arrested for public intoxication in Iowa City after he mistook a police car for an Uber. Both Reiff and Wirfs have been suspended for the Hawkeyes' Sept. 1 opener against Northern Illinois.
"Two of our players were arrested on alcohol-related charges," coach Kirk Ferentz said Tuesday. "As a veteran football coach and parent, I understand firsthand the personal pain and public humiliation that comes with making such decisions. While these players are college students first, they are held to a much higher standard because of the privilege and responsibility that comes with being a member of the Iowa football program."