The school announced the severity of Moore's injury Friday, saying he will need up to 12 weeks to recover once he has surgery on his right ankle.
The senior was hurt while running 27 yards for a touchdown Tuesday night during a 35-9 victory at Arkansas State.
His college career ends with 3,570 yards rushing and 33 touchdowns. He had 400 yards and six touchdowns in five games this season.
"I hate this for Jalin," coach Scott Satterfield said, adding that the running back will "remain a leader on this team, just in a different role."