The game will be played in Atlanta on Sept. 5, 2015.
Louisville athletic director Tom Jurich has been working to upgrade the Cardinals' schedule. There shouldn't be too many complaints moving forward.
Not only will Louisville be in the ACC in 2015, it will be taking on a second SEC opponent in nonconference play, with rival Kentucky already on the slate.
This will be Louisville's first appearance in the game. Auburn, meanwhile, played in the Chick-fil-A Kickoff Game against Clemson last year.
"Louisville and Auburn represent two great football brands with incredible fan bases and a tradition of winning," Gary Stokan, Chick-fil-A Bowl president and CEO, said in a statement. "The ACC vs. SEC is a tremendous rivalry that has proven to be a recipe for sellouts, high TV ratings and close, competitive games."
Auburn and Louisville have met only once, in 1974. The Tigers defeated the Cardinals 16-3 at Legion Field in Birmingham.