Nkemdiche injured his knee in the opener against Vanderbilt but was able to practice Tuesday.
"The big question was: Would there be a lot of swelling in the knee? We were pleased that he did not have any and feel very good about it," Ole Miss coach Hugh Freeze said. "He'll go through practice [Wednesday], and we'll check it again Thursday morning. If it looks Thursday morning like it did today, then he'll be ready to go."
The Rebels were already extremely thin at linebacker, so getting Nkemdiche back for the No. 1 Crimson Tide would be huge for Ole Miss. He led the Rebels in tackles (82) and tackles for loss (13) last season as a redshirt freshman. In a 33-14 loss to Alabama a year ago, Nkemdiche had three tackles for loss and two forced fumbles.
Ole Miss will also get back receiver Vincent Sanders for this game. Sanders broke his collarbone during preseason practice and missed the Rebels' first three games. His 39 catches ranked third on the team last season.