Denson was a starter for the Tigers and had three catches for 45 yards through four games.
"That's a big blow for our offense," Malzahn said on the SEC coaches' call. "He was our most consistent guy. It's going to have to be by committee from here on out. It's good that we have an off week that we can start working some guys, and right now, we're rotating a whole bunch of guys. After this week, we'll kind of settle in on our plan moving forward."
After the LSU game, Denson tweeted that he tore his patellar tendon, but there's no been official word from the university. He underwent surgery Tuesday, according to his Twitter account. He plans to return next season.
"I'm down ... But best believe I'm not out," Denson tweeted. "The SEC has not seen the last of me! I will bounce back."
Malzahn said the injury would create opportunities for others. Sophomore Sammie Coates emerged against LSU, catching four passes for a team-high 139 yards. Quan Bray, Marcus Davis and Ricardo Louis have also been in the mix this season, and freshman Tony Stevens saw his first action of the year after Denson went down.
Injuries have been a persistent problem this season for the Tigers (3-1, 1-1 SEC), who are off until a home game Oct. 5 against No. 21 Mississippi (3-0, 1-0).
"I don't think I've been around a team that had that many [injuries] this early and to main impact players," Malzahn said. "Defensively, we've been playing without a lot of our impact players, and even when we get them back, they're not quite 100 percent yet. But they're getting there."