The star sophomore was dressed in street clothes and was wearing a walking boot on his left foot when the Bulldogs returned to the field for the second half.
"He sprained his ankle. I'm not sure how bad it is. We'll just have to see," Georgia coach Mark Richt said on CBS before the start of the second half.
Richt said after the game he wasn't sure how long Gurley will be out.
Gurley limped across the field to the Bulldogs' sideline immediately after breaking a 23-yard run to the 50 with approximately 11 minutes remaining in the first half. After team trainers examined his ankle on the sideline, he jogged to the locker room, where he spent the next several minutes.
Gurley returned to the sideline late in the second quarter, but never returned to the field after injuring the ankle. He had rushed eight times for 73 yards when he went down.
Keith Marshall took over in Gurley's place and finished with 20 carries for 96 yards. The Bulldogs outgained the Tigers on the ground 143 yards to 13 in the opening half and 196 to 77 overall.
Information from The Associated Press was used in this report.