The freshman forward has what the school calls a mild right knee sprain, and he was held out as a precaution.
The 6-foot-11 Bagley is the ACC's leading scorer and rebounder, averaging 21.2 points and 11.4 rebounds this season.
He was injured in the first half of Thursday's 82-78 loss to North Carolina, but he finished with 15 points and 16 rebounds for his 18th double-double.
With Bagley out, senior Grayson Allen led the Blue Devils with 23 points, four rebounds and six assists as Duke snapped a two-game losing streak.
The Blue Devils next play at home Wednesday night against Virginia Tech at 7 p.m. on ESPN2.