Both were in the lineup against the Chicago White Sox for Monday night's 4-0 win as the Rangers opened a six-game home stand at Rangers Ballpark.
"I'm sure there will be anxiousness and nervousness the first couple of at-bats,'' Hamilton said, "but I feel good."
"I'm not going to change the way I play the game,'' he added.
Hamilton wasted no time getting back in the swing of things. He homered off White Sox starter John Danks in the first inning.
Hamilton went on the DL on April 13 with a fracture of the right humerus bone suffered with a head-first slide at home plate.
Cruz was been out since May 4 with a strained right shoulder quadriceps muscle.
"I got everything accomplished in my rehab starts that I needed and I'm excited to be back,'' said Cruz.
Cruz also went deep, sending a 2-run shot over the wall during the bottom of the sixth inning.
Hamilton was the DH and batted third in manager Ron Washington's order. Cruz started in left field and hit sixth.
Yoshinori Tateyama, a 35-year-old right-handed reliever at Triple-A Round Rock, also joined the team Monday. In 14 appearances, Tateyama was 1-0 with a 2.14 ERA for the Express.
Tateyama, a sidearm pitcher, had a career-low 1.80 ERA in 58 appearances for the Hokkaido Nippon-Ham Fighters in the Japanese Pacific League in 2010 with four saves and 25 holds.
Cruz was 7-of-22 overall in six rehab games, including home runs in each of his three games for Round Rock. Hamilton homered twice in his five minor league games as the DH.
Before getting hurt, Hamilton was hitting .333 in 11 games without a home run. Cruz hitting just .219 with seven homers and 18 RBIs in his first 30 games with Texas.
When Hamilton got hurt, the Rangers expected him to be out six to eight weeks. His return came one day short of six weeks and on the same night of a promotional giveaway at Rangers Ballpark recognizing his 2010 MVP season.
"Yeah, just in time for Hamilton figurine night," he said. "It looked kind of terrible -- they keep hiding my face."
The figurines feature Hamilton making a catch with his arm extended in front of him.
Randy Jennings is a contributor to ESPNDallas.com. Information from The Associated Press was used in this report.