Beltre, who hit fourth but started as the designated hitter, was 2-for-3 with a pair of RBIs before he was lifted for pinch hitter Jim Adduci in the sixth inning.
The Rangers are sending Beltre back to Texas to have the quad examined by Dr. Keith Meister, general manager Jon Daniels confirmed. The team purchased the contract of infielder Kevin Kouzmanoff, who hasn't played in the majors since 2011, from Triple-A Round Rock on Wednesday and designated pitcher Seth Rosin for assignment.
Beltre had the same problem in spring training, and Rangers manager Ron Washington said the team wanted to get him checked out as quick as possible.
In his pregame remarks Washington said Beltre was given the day off from his third-base duties to give him a day off from playing the field.
After an RBI double in the fourth, Beltre was unable to run following Michael Choice's fielder's choice, and he struggled getting to the Rangers' dugout at the completion of the frame.
Scott Barboza is a contributor to ESPNDallas.com.