Lee, who missed last week's win over the Seattle Seahawks due to a dislocated wrist, has been a limited participant in practice all week. He wears a heavily wrapped cast on the field, preventing him from being able to use any of the fingers on his left hand.
Lee, who leads the Cowboys in tackles and interceptions, said earlier this week that the pain in the wrist is much less than he anticipated. However, the coaching staff isn't certain how much they can count on Lee in Sunday's game against the Buffalo Bills.
"Honestly, we hope he can play," defensive coordinator Rob Ryan said. "He brings so much to the defense. He's smart, tough, he finds the football like no other."
Jones has not practiced since suffering a high ankle sprain in the Oct. 16 loss to the New England Patriots. He is listed as out along with receiver Miles Austin and cornerback Mike Jenkins, who are both dealing with hamstring injuries that are expected to sideline them for at least three games.
Punter Mat McBriar, who did not play last week due to a nerve condition called "drop foot" in his left leg and foot, is listed as questionable. McBriar said Friday that he believes he will be able to play.
Right guard Kyle Kosier is also listed as questionable, as he has been for several weeks. Kosier hasn't missed a game despite a partially torn plantar fascia in his left foot.
Tim MacMahon covers the Cowboys for ESPNDallas.com.