Scherzer (13-1) was trying to become the first pitcher in the majors to start 14-0 since Roger Clemens in 1986. He allowed four runs and eight hits in six innings, walking two and striking out six.
It was Scherzer's first regular-season loss since Sept. 23, a span of 21 starts.
Mitch Moreland's two-run homer in the fourth gave Texas a 3-0 lead, and for once, the AL Central-leading Tigers didn't back Scherzer with much offensive support. Derek Holland (8-4) allowed a run and five hits in seven innings.
Adrian Beltre added a two-run homer in a three-run ninth for Texas.
INDIANS 5, ROYALS 3
Chisenhall's homer in the sixth broke open a 1-0 game and hit off the facing of the second deck in right field, landing in Kansas City's bullpen.
Kazmir (5-4) allowed two runs in 6 1-3 innings for his first victory since June 21 as the Indians won for the fifth time in seven games.
Miguel Tejada's RBI single in the seventh broke a streak of 22 consecutive scoreless innings for Kansas City, which has lost four in a row.
RAYS 4, ASTROS 3
ST. PETERSBURG, Fla. -- Luke Scott had a go-ahead RBI single in the sixth inning and a two-run homer in the fifth, leading the Rays to a victory over the Astros.
Roberto Hernandez survived a shaky first inning to post the Rays' 14th straight quality start, going six innings and giving up three runs and six hits. He won for the first time in six starts since June 11. Hernandez (5-10) struck out six.
Brett Wallace homered for the Astros, losers of 11 of 14.
Lucas Harrell (5-10) gave up Scott's RBI single in the sixth.
BLUE JAYS 7, ORIOLES 3
Davis increased his major league-leading home run total to 36 with his third long ball in three games.
Baltimore led 3-2 before the Blue Jays took the lead in the sixth against Jason Hammel (7-6).
Aaron Loup (4-3) got the victory with 1 1-3 innings of hitless relief.
TWINS 4, YANKEES 1
Trevor Plouffe, Ryan Doumit and Pedro Florimon connected against Hughes -- all on 2-2 pitches. Minnesota snapped a six-game losing streak with its second victory in 14 games, winning for the first time in six meetings with the Yankees this year.
New York won 32 of the previous 39 matchups, including a pair of playoff sweeps.
Beaten by Hughes earlier this month, Deduno (5-4) scattered six hits in his first start at Yankee Stadium. He struck out three, walked three and matched the longest outing of his career.
Hughes (4-9) tied a career high with 10 strikeouts in 7 1-3 innings.
Copyright 2013 by The Associated Press
This story is from ESPN.com's automated news wire. Wire index
MORE MLB HEADLINES
- Majestic Youth Replica Baltimore Orioles Adam Jones #10 Cool Base Home White Jersey