Letang returned from the IR on Tuesday night after missing three games due to the injury. He appeared in some discomfort following his first shift but played more than 24 minutes in a 1-0 win over the Montreal Canadiens.
Despres, brought back up early Wednesday, has played well during his first season and his plus-10 plus/minus rating ranks in the top 10 among rookies.
Pittsburgh goaltender Marc-Andre Fleury also sustained an undisclosed injury Tuesday after colliding with a pair of players in the second period. Fleury did not return for the third period and is being re-evaluated Wednesday.
Copyright 2013 by The Associated Press
This story is from ESPN.com's automated news wire. Wire index