With some teams potentially resting starters for the playoffs in Week 17, this week could be the last chance to load up on certain fantasy stars in the regular season ... if they aren't among the big names already lost in a brutal season that will now be without Aaron Rodgers (again) and Antonio Brown for the final two weeks.
We'll focus on some of the best plays in Saturday-only and Monday-only contests this week, but Sunday's slate should be headlined by the return of Ezekiel Elliott in Dallas. You'll want to mark that game against Seattle as one of the main fantasy opportunities this weekend, along with Falcons-Saints and Dolphins-Chiefs.
Here are the best and worst fantasy matchups for Week 16:
(Note: References to defensive rankings are based on Football Outsiders' DVOA metric, explained here.)