Because the brackets have been set, Holmes will take Clark's position in the draw. He will face Camilo Villegas in the opening round.
Clark won The Players Championship a year ago and was the No. 22 seed. He has not played since he tied for second in the Sony Open at Honolulu last month.
Holmes has played the Accenture Match Play Championship only one time, losing to Tiger Woods on the 18th hole in the opening round.