Moore won the Justin Timberlake Shriners Hospitals for Children Open on Sunday for his second PGA Tour title, birdieing the par-5 16th to take the outright lead and finishing with two pars for a 5-under 66 and a one-stroke victory over de Jonge.
"The last couple of days were tough," said Moore, the former UNLV player who lives in Las Vegas. "I was shot for shot with Brendon, and he was playing some great golf. I was able to make a birdie down the stretch when it mattered to hold him off at the end."
Tied with de Jonge and Jonas Blixt after the third round, Moore finished at 24-under 260 at TPC Summerlin and earned $810,000 in the Fall Series opener. Moore also won the 2009 Wyndham Championship.
De Jonge shot a 67.
"He was playing great and he was hitting the ball really well, and he was making putts," Moore said. "I tried not to get too wrapped up into what he was doing really for the last two days. I just tried to keep my head and just keep hitting my golf shots, and playing the golf course how I wanted to play it and just give myself opportunities."
De Jonge, from Zimbabwe, missed the fairway on the 560-yard 16th.
"Today, playing a little bit down breeze, all you've got to do is get one in the fairway," de Jonge said. "It's almost a mid-iron in there, so that was definitely a turning point, you know, the bad tee shot there."
Blixt had a 70 to finish third at 20 under.
Jason Day pulled within three strokes of Moore and de Jonge with a birdie on No. 16, but closed with a double bogey on the par-4 18th. He had a 65 to finish fourth at 18 under.
"The only blemish was obviously the missed green on 18," Day said. "But I thought I was going to shoot 59 today, just the way things were going. I was hitting it good. I was putting it good, too. I just didn't capitalize on the opportunities I had on the back nine."
Moore birdied the second and third holes to take a one-stroke lead over playing partners Blixt and de Jonge, and birdied the seventh hole to move two shots ahead.
De Jonge pulled even with birdies on Nos. 8 and 9 and they remained tied through 15, going to the 16th tee at 23 under.
"I played nicely all week," de Jonge said. "Hats off to Ryan. He played great, especially down the stretch. He made a couple tough shots in there on 17 and 18, and he pulled them off when he needed to."
Bill Lunde was fifth at 15 under after a 66. He jumped from 157th to 128th on the money list, with the final top 125 getting full tour cards for next season.
John Daly, tied for sixth at 10 under after a season-best 63 on Friday, followed a 15-over 86 on Saturday with a 6-over 77 on Sunday to finish last at 11-over 295. He dropped from 132nd to 137th on the money list.