The games will be played March 22-23 at Sydney Cricket Ground.
Kershaw will be making his fourth straight season-opening start for Los Angeles, becoming the first Dodgers pitcher since Ramón Martínez from 1995-98 to earn the nod four consecutive seasons.
Manager Don Mattingly made the announcement Sunday after weeks of speculation about who would start in Australia.
Ryu got the start in Game 2 because of an injury to Zack Greinke, who strained his right calf while throwing four pitches in his only spring appearance on Feb. 27 against Arizona.
Before getting hurt, Greinke said there was "zero interest" in making the long trip. He is not expected to travel.
Greinke was scheduled to throw a bullpen session Monday.
Information from The Associated Press was included in this report.