The team is already without highly touted freshman guard Kasey Hill with a similar injury. Hill, who has averaged 10 points in four games, may need another two weeks to rehab, coach Billy Donovan said prior to Florida's game Monday night at No. 12 Connecticut.
Wilkbekin was injured with three minutes remaining in Monday's buzzer-beating 65-64 loss to the Huskies. Shabazz Napier took advantage of Wilkbekin's absence, converting a four-point play and the game-winning shot. Before leaving, Wilkbekin had 15 points, making 6 of 14 shots.
Florida announced Tuesday that X-rays on Wilbekin's right ankle were negative but gave no timetable for his return.
Wilbekin had recently returned from a six-game suspension (one exhibition, five regular season). He scored 12 points in his season debut against Jacksonville but went 2 for 12 for seven points in a one-point win over Florida State.
The Gators host No. 6 Kansas on Dec. 10 in the SEC-Big 12 Challenge and will be without a true point guard if neither Hill or Wilbekin return in time.
Florida's roster is already depleted with Damontre Harris indefinitely suspended and Eli Carter likely seeking a medical redshirt. The Gators can get McDonald's All-American forward Chris Walker back if he passes his last online class and is deemed NCAA eligible in time for a Jimmy V Classic game against No. 16 Memphis on Dec. 17 in New York City.