Henderson suffered the injury at 11:15 of the first half of Vanderbilt's 69-67 win over Marshall, right after back-to-back blocks by his teammates on a Marshall fast break.
Henderson, a junior, was averaging 7.6 points, 4.6 rebounds and 0.4 blocks in 21.3 minutes per game this season.
Dai-Jon Parker sank a 3-pointer just inside the final minute to give Vanderbilt a 69-65 lead after Canty's 3-pointer had cut what had been a 13-point lead to 66-65. Shawn Smith sank his final two free throws, and Marshall had a chance to tie it before Siakam stole the ball.
The Associated Press contributed to this report.