Spartans coach Tom Izzo said he doesn't "think it's anything serious.''
Ward went down midway through the first half and pounded the court with both fists. He got up on his own and hobbled off the court, trying to keep weight off his right leg. He did not return.
Izzo said it's a low ankle sprain, which generally heals faster than a high ankle sprain.
Ward had four points, three rebounds and a block in five minutes.
The 6-foot-9 forward is averaging 17 points, ranking second on the team, with a team-high 7.5 rebound average.
He returned to school for his junior season after initially putting his name in the NBA draft.