He scored 13 points in his team's 77-58 victory over St. John's on Sunday.
Southerland had missed the last six games for No. 9 Syracuse (20-3, 8-2 Big East) after being declared academically ineligible. Several reports said that the NCAA was looking into his academic record.
Southerland appealed the decision, and his appeal was heard last week.
The second-leading scorer before being declared ineligible, Southerland's return is a big boost for Syracuse.
The Orange were 4-2 without him, missing his ability to stretch the defense with his 3-point shooting. He averaged 13.6 points and connected on 37 percent from outside the arc.