The Reds said Friday they expect to recall Thompson from Triple-A Louisville to make his major league debut Saturday in Yankee Stadium.
In 14 starts this season at Louisville and Double-A Chattanooga, Thompson was 6-2 with a 2.22 ERA. He pitched last year in Single-A.
Thompson was part of an eight-player trade in 2006 between the Reds and Washington.
He replaces 22-year-old Homer Bailey, who returned to Louisville with an 0-3 record.