"The last thing I want is surgery," Lowrie said Friday, according to the Boston Herald. "But if it's something that will make this better and be the long-term solution, I'll do it."
The Red Sox placed Lowrie on the 15-day disabled list Monday before their game against the Oakland Athletics.
Lowrie was then sent to Boston for initial tests on the wrist.
According to The Boston Globe, Lowrie said his options included playing with cortisone shots, having a fractured bone -- the ulnar styloid -- reattached or removing the wrist bone entirely. Removing it would end his season, he said.
Lowrie played with an injured left wrist for much of the second half of last season, although manager Terry Francona said he wasn't sure if this year's injury was in the same place.
Lowrie told Francona about new soreness Sunday.
"The first question I'm asked is if I'm depressed, feeling down," Lowrie said, according to the Herald. "Maybe I'm in better spirits because I have more questions than answers. Maybe I need surgery. It's about me finding out what I need to do and embarking on that to get myself healthy. I'm optimistic about it. I'm optimistic to get as much info as I can and go forward from there."
Lowrie was stuck in a 1-for-18 rut to begin the season after hitting .343 with three homers and 16 RBIs in spring training.
He batted .258 with 46 RBIs in 260 at-bats last year in his first major league season.
"I'm not going in wanting surgery," said Lowrie, who will see Dr. Donald Sheridan, a Scottsdale-based orthopedic surgeon. "But if that's what it's going to take for me to feel good, then that's what I'm going to do."
Utility infielder Nick Green has replaced Lowrie at shortstop, going 5-for-15 with three RBIs in five games.
Information from The Associated Press was used in this report.