After meeting with Dr. Donald Sheridan, an orthopedic surgeon based in Arizona, on Monday, Lowrie is leaning toward having surgery on his left wrist in the next couple of days, according to multiple media reports.
The good news?
Lowrie could be back as soon as the All-Star break.
"I think there's a pretty good chance that he's going to have a surgery in the next day or so, but we're still having some internal discussions," Red Sox manager Terry Francona said, according to MLB.com.
"I wasn't available most of the day but [general manager] Theo [Epstein] has been. In saying that, I think it's generally pretty good news. I think the medical people think that even with the surgery that he would be having, he could be playing by the All-Star break. That's where we're at today. We'll obviously know more [later] or tomorrow."
The Red Sox placed Lowrie on the 15-day disabled list Monday before their game against the Oakland Athletics.
Lowrie was then sent to Boston for initial tests on the wrist.
He was stuck in a 1-for-18 rut to begin the season after hitting .343 with three homers and 16 RBIs in spring training.
Lowrie batted .258 with 46 RBIs in 260 at-bats last year in his first major league season.
Information from The Associated Press contributed to this report.