Uehara had been trying to rehab his elbow in time to return to the last-place Orioles this month as a reliever, a role he could fill next year.
The team hoped he would be able to face hitters in a simulated game this weekend in New York, but manager Dave Trembley said the right-hander felt he wasn't ready and asked for another week without throwing.
"If he took another week off and then started a throwing program again, the season would be over," Trembley said. "So we're going to go with a cautious approach here and just shut him down completely and prepare him for next year."
Baltimore's first Japanese-born player, Uehara signed a two-year contract in January. The 34-year-old rookie has been out since June 24 with tendinitis in his right elbow. He finishes the season 2-4 with a 4.05 ERA in 12 starts.
Trembley said Uehara will be put on the same offseason throwing program as Baltimore's other pitchers, which means he would start throwing in mid-December to prepare for spring training.
In other news, reliever Kam Mickolio has inflammation in his right biceps and won't be with the team during its weekend series at Yankee Stadium. He is expected to rejoin the Orioles on Monday in Baltimore and be re-evaluated.
Mickolio was sent home Wednesday from Boston to get his pitching arm examined by team doctors. He is 0-2 with a 2.63 ERA in 11 relief appearances for the Orioles this season.