Toronto recalled infielder Mike McCoy from Triple-A Las Vegas.
Encarnacion had surgery to remove a bone spur from his wrist in the offseason and missed three games last week after aggravating the injury while diving for a ball on defense.
John McDonald took over at third base in the eighth inning Saturday and is expected to get the bulk of the playing time while Encarnacion is sidelined.
Major league home run leader Jose Bautista has made 35 appearances at third for Toronto this season, but manager Cito Gaston said he'd prefer to keep Bautista in right field.
Encarnacion is batting .246 with 13 homers and 36 RBIs in 80 games. He missed 30 games in April and May with a sore right shoulder.