Denard Span hit a hard chopper for the Twins to start the third inning of Tuesday night's game that took a tough bounce at Butler and grazed his right, non-gloved, hand.
The ball skipped by him into right field, and Butler immediately winced in pain. He was doubled over with his hands on his knees for a few seconds before walking to the mound with pitcher Brian Bannister. Then he headed for the dugout after a brief conversation with manager Ned Yost and a team athletic trainer.
Butler was replaced by Kila Ka'aihue. The Royals said X-rays on Butler's hand were negative. Yost said he wouldn't play on Wednesday.
"It's the same hand that he's been struggling with for awhile, and it hit him in the exact same spot," Yost said.
Butler flew out to right in his only at-bat of the game.
Information from The Associated Press was used in this report.