SAN DIEGO -- Jake Arrieta threw eight scoreless innings of two-hit ball to become the NL's first 16-game winner and Kris Bryant and Addison Russell homered, leading the Chicago Cubs over the San Diego Padres 5-3 on Tuesday night.
Bryant's 33rd home run tied him with Colorado's Nolan Arenado for the NL lead.
Russell smacked his fifth homer in five games, a two-run shot that put the Cubs ahead 4-0 in the fifth.
Arrieta won for the fourth straight start. He had six strikeouts and three walks.
The major league-leading Cubs are 21-5 in their last 26 games and 35 games over .500 for the first time since Sept. 25, 2008.
Chicago has scored at least three runs in 22 straight games and has hit a minimum of two home runs in each of its last seven outings.
Christian Friedrich (4-10) lost his eighth consecutive decision. He lasted 5 1/3 innings, giving up five runs and seven hits. He walked four and struck out two.
Bryant got his second RBI in the sixth when his sacrifice fly scored Arrieta, who was aboard on a one-out triple.
In the Cubs' three-run fifth, Ben Zobrist stroked a run-scoring double which preceded Russell's long fly. Zobrist had three hits.
Bryant, who won the Golden Spikes Award at the University of San Diego, hit his second home run in two games in the third. His one-out blast put the Cubs ahead 1-0.
The Padres blew several chances early.
Travis Jankowski was picked off third in the first, and Arrieta, who is 27-5 since the beginning of last August, wiggled from jams in the next two innings thanks to two double plays, the first of three for the Cubs.
Cubs: RHP John Lackey (right shoulder strain) is progressing with his throwing program and will have a bullpen session this weekend in Los Angeles.
Padres: RHP Tyson Ross (right shoulder strain) will have a 45-pitch outing on Thursday for Class A Lake Elsinore. Ross was the Padres' opening day starter and hasn't pitched since.
Cubs: RHP Kyle Hendricks (11-7, 21.6) has 16 straight starts in which he's allowed three runs or fewer, the longest streak in the majors this season. He's 2-0 with a 1.26 ERA in four starts against the Padres. Hendricks has won all but three road games this year.
Padres: Paul Clemens (2-2, 4.82), who was claimed off waivers last month, worked five innings in his last outing on Thursday but didn't figure in the decision. He surrendered three runs on eight hits and three walks to the Arizona Diamondbacks.