Greinke will be pitching on three days' rest for the second straight turn.
With the Brewers trying to nail down home-field advantage in the first round of the playoffs, Greinke pitched six innings and got the win in Wednesday's season finale against Pittsburgh. Greinke's previous start came Sept. 24 against Florida.
The decision to start Greinke on short rest allows Milwaukee to start Shaun Marcum in Game 3 at Arizona. Marcum was 5-4 with a 4.81 ERA at home and 8-3 with a 2.21 ERA on the road this season.
Yovani Gallardo will pitch Game 1 on Saturday.