Upton, who entered the game hitting only .186, had a two-run homer and three singles after striking out in his first two at-bats. The single in the 11th off Ryan Webb (1-5) drove in pinch-runner Paul Janish from second base.
Luis Ayala (1-1) pitched a scoreless 11th.
With two outs, Webb walked Dan Uggla, bringing Upton to the plate.
Royals outfielder Jorge Soler suffered a fractured toe while tripping exiting the batter's box and could be out "a while," manager Ned Yost said.
Former Blue Jays infielder Kelly Gruber was pulled from Canadian Baseball Hall of Fame induction weekend festivities for "unacceptable and inappropriate behavior."
This weekend's series in Arlington, Texas, is a homecoming for Colorado Rockies shortstop Trevor Story, who grew up coming to Texas Rangers games and is playing in the stadium for the first time with the goal of doing some damage to the team he used...
The Toronto Blue Jays continue to wait for the return of third baseman Josh Donaldson from tightness in his left calf.
Having dipped into the minor leagues for four new players Friday, the Los Angeles Angels plan to do so again Saturday for their starting pitcher when they go for a second straight win against the Oakland Athletics.
Kyle Seager was asked before Thursday's series opener against the Boston Red Sox what it's like to face a knuckleball pitcher.