The game in Detroit was called more than three hours before the scheduled first pitch, with rain in the area expected to linger throughout the day.
There was no makeup date immediately announced. The Tigers took two of three in what was initially supposed to be a four-game series.
Detroit heads off to begin a series at Oakland on Friday night, while the Indians continue their road trip at Kansas City.
The rainout could help a Cleveland team that just put ace right-hander Corey Kluber on the disabled list .
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The Marlins victory over the Dodgers Wednesday night was the biggest baseball betting upset for Las Vegas books since 2007.
Boston has approved a plan to change the name of Yawkey Way, the street outside Fenway Park named in honor of a former Red Sox owner some have said was racist.
The Reds activated third baseman Eugenio Suarez from the 10-day disabled list and promoted Rosell Herrera from Triple-A Louisville before Thursday's game against the Braves.
Play Javier Baez at shortstop full time? Every club has a move that could improve its 2018 before it's too late.
A slow start has buried the Orioles' chances of making a last run at the postseason, forcing a tough choice for their front office.
Shohei Ohtani's blisters have become calloused, and Angels manager Mike Scioscia says the two-way star is confident the problem is behind him.