The game in Detroit was called more than three hours before the scheduled first pitch, with rain in the area expected to linger throughout the day.
There was no makeup date immediately announced. The Tigers took two of three in what was initially supposed to be a four-game series.
Detroit heads off to begin a series at Oakland on Friday night, while the Indians continue their road trip at Kansas City.
The rainout could help a Cleveland team that just put ace right-hander Corey Kluber on the disabled list .
More AP baseball: https://apnews.com/tag/MLBbaseball
Players' association rejects MLB's proposal to institute 20-second pitch clocks, limits on mound visits
The players' association rejected Major League Baseball's proposal to institute 20-second pitch clocks and limits on mound visits, a move that dares management to unilaterally impose the changes designed to speed the pace of games, two sources told ESPN.
Michael Wilbon and Tony Kornheiser discuss the proposed pitch clock for Major League Baseball and whether it will help cut down on game times.
Outfielder Howie Kendrick and the Washington Nationals have finalized their $7 million, two-year contract.
The Minnesota Twins have hired former starting pitcher Jim Kaat as a special assistant to the organization.
The Pirates have signed left-handed reliever Felipe Rivero to a four-year contract that runs through the 2021 season. The deal includes club options for 2022 and 2023.
Adrian Gonzalez vows to have a quiet voice with the New York Mets.