It was assumed Acta would give the ball to Carmona, who won 13 games last season. Acta confirmed Carmona will face the White Sox following Cleveland's exhibition win Monday over Cincinnati.
Carmona has bounced back from a brutal 2009 season, when he was sent to the lower minor leagues to work on his mechanics. The Indians are hoping the right-hander, who won 19 games in 2007, can stay consistent and anchor their starting staff.
This will be Carmona's first opening day start.
He made his spring debut on Monday, pitching two scoreless innings in the Indians' 12-0 win over the Reds.