First-year manager Bryan Price said Thursday that Cueto will pitch Monday at home against St. Louis.
Price had to sort through a series of minor injuries, including Cueto's tender right shoulder, before making the final determination. Cueto missed a turn this spring because of soreness.
"When Johnny's been healthy, he's been our No. 1 starter, legitimately for the previous four years," Price said. "Keeping him healthy is the key. He only made 11 starts for us last year. Yesterday, I had him long toss. I asked him how he felt after it then made the decision."
Tony Cingrani will pitch the second game. He was the only starter in the rotation without an injury issue this spring.
Brett Marshall is slowed by a strained tendon in his middle finger, and he will see a hand specialist in Phoenix on Friday.
Mesoraco hasn't played in 10 days with a strained oblique.
"Devin has to play. He has to catch, throw, hit and run. It is unlikely that he will join us but we haven't signed off on putting him on the disabled list," Price said.