"He was sick, but because he got that foul tip, we had to be cautious," Francona told the Cleveland Plain Dealer. "We don't know if he's sick or he has concussion-like symptoms, so we sent him back to the hotel and we'll re-evaluate him and we'll go from there."
Santana, who also plays third base, was originally supposed to be the Indians' designated hitter on Monday. He is hitting .159 this season with six homers and 17 RBIs.
The Indians, who won 92 games and made the playoffs as a wild card team last season, trail Detroit by 6½ games in the AL Central.