Gonzalez left Friday's game at Arizona after going 0 for 3 with three strikeouts. It is his second trip to the DL this season after inflammation in his left index finger sidelined the slugger for five weeks.
"You can see mental stress on him, you can see physical stress," Rockies trainer Keith Dugger said. "He made the decision to take time off, so that's where we are right now. We're going to get that ankle right. We know he's got tendinitis, we've been dealing with it. We know it isn't going away overnight or even in a week."
Gonzalez is batting .238 with 11 homers and 38 RBIs in only 70 games this season.
"We felt like it got to a point where it wasn't getting any better," manager Walt Weiss said. "Defeating the purpose to send him out there ... give him some time for those nagging injuries to calm down."
Weiss added that he'd like to see Gonzalez play again this season, hopefully.
The Rockies recalled Ben Paulsen from Triple-A Colorado Springs to replace Gonzalez on the roster, and Paulsen was in the lineup at first base on Sunday.
Last-place Colorado, beset with injuries all season long, got more bad news before its series finale against the Diamondbacks.
Left-hander Brett Anderson will see a spine surgeon on Monday in Scottsdale, Arizona, to address a bulging disk in his lower back. Anderson, who missed three months earlier this season with a broken left index finger, was placed on the DL on Wednesday. He is 1-3 with a 2.93 ERA in eight starts this season.
"He's having some issues, not so much back pain but pain going down his leg," Dugger said. "It's not a quick fix by any means, even if we go the non-surgery route."
Star shortstop Troy Tulowitzki remains on the disabled list with a left hip flexor strain but is feeling better, Dugger said.
"He still has some on and off discomfort in the front of the hip there," he said.
Dugger said Tulowitzki could have a torn labrum in his hip. He's still not ready for a rehab assignment despite having been out since July 22, though he is working out.