Starting for the second time in three days, Buehrle needed two innings Sunday to reach the milestone, but he failed to get through the first against Tampa Bay.
"This game is crazy," Buehrle said. "I felt great and didn't get out the first inning. It wasn't meant to be."
Two errors led to Buehrle allowing eight unearned runs and five hits over a career-low two-thirds of an inning. He had gone 6 2/3 innings Friday night en route to his 15th win.
David Price is scheduled to start Game 1 of the Blue Jays' AL Division Series on Thursday at home against AL West champion Texas. Toronto ended the regular season at 93-69, a 10-game improvement over last season.
It didn't come as a surprise that Buehrle will not be on the active roster for the Rangers series.
"They've already talked to me," Buehrle said. "It's tough. We've had four guys [pitching well]. They made the right decision."
Buerhle also said he has not decided if he will be retiring.
"I don't know what's going to happen," Buerhle said. "I'm going to go home and talk with my wife. We'll figure it out and let you guys know in a couple months."
Tim Beckham drew a two-out, bases-loaded walk and Joey Butler hit a grand slam on an 85 mph offering -- the fastest of Buehrle's 45 pitches -- to make it 6-0. The slam came after a close call by plate umpire Alfonso Marquez went against Buehrle on a 2-2 pitch.
Manager John Gibbons took Buehrle out after Brandon Guyer's RBI single.