Fielder, 32, hasn't played since July 19 after an MRI revealed a herniation of disks in his neck just above an area that was repaired two years ago.
According to Fox Sports, which first reported that Fielder would not play again, the slugger had season-ending neck surgery last month.
Fielder is hitting .212 with eight home runs and 44 RBIs this season. He has 319 career home runs in 12 seasons for the Brewers, Tigers and Rangers.
If his career is over, Fielder will finish with the same career home run total as his father, Cecil, who was a major leaguer for 13 seasons with five teams.
The six-time All-Star is scheduled to receive $24 million annually through 2020 as part of the nine-year, $214 million deal he signed with the Tigers in 2012.
The Tigers traded him to the Rangers in the 2013 offseason in exchange for second baseman Ian Kinsler.
Fielder was the seventh overall pick by the Brewers in 2002. He made his major league debut with Milwaukee in 2005.