During an at-bat in the sixth inning Monday night, Ramirez was struck by the ball after an inside pitch by Warwick Saupold caromed off his bat. He started toward first base, stopped and waited for a trainer before walking off the field with manager Terry Francona.
The Indians announced that Ramirez was removed for precautionary reasons.
Ramirez, who hit a two-run homer in the fourth inning to give Cleveland a 7-0 lead, is among the AL leaders in several offensive categories.
He is batting .308 with 26 homers and 73 RBIs. He leads the league with 47 doubles and 79 extra-base hits.
Ramirez recently missed several games because of a sore right wrist.