The Cardinals made the move Saturday after Holland's ERA ballooned to 9.45 following a bumpy inning of work Friday night in an 8-1 loss to the Pittsburgh Pirates. Holland, a three-time All-Star, allowed two runs on three hits. He has surrendered two runs in each of his last four appearances.
Manager Mike Matheny gave no timetable for Holland's possible return.
St. Louis activated left-handed reliever Tyler Lyons (back strain) and catcher Carson Kelly (hamstring) off the disabled list. To make room for Kelly, the Cardinals optioned catcher Steve Baron to Triple-A Memphis.