Polanco hit a triple in the first inning, a single in the third, a home run in the fifth and a double in the seventh. He added a single in the ninth for his first five-hit game.
"I feel really good at the plate, waited for my pitches in the zone and got my hits,'' Polanco said.
Polanco knew what he needed to do in the seventh inning to complete the cycle, according to the St. Paul Pioneer Press.
"I think that the inning before, I was thinking that I needed a double," Polanco said. "But when I went to hit, I was just thinking to get a good pitch and hit it."
It was Polanco's first career cycle, the 15th in franchise history and the 11th since the franchise became the Twins upon relocating from Washington, D.C., for the 1961 season. Michael Cuddyer was the last to hit for the cycle for the Twins, doing so on May 22, 2009, against the Brewers.
It was the first cycle in the major leagues this season.
Information from The Associated Press was used in this report.