The team had been hoping Pedroia could play three consecutive games in Double-A Portland in preparation for rejoining the big club, but he was scratched from Saturday's game with the knee issue. Pedroia had played five rehab games with the Sea Dogs, going 4-for-16.
The Boston Globe reported that Pedroia will go back on his rehab assignment after a short delay, noting that rehab windows last only 20 days, and Pedroia needed a reset because he would not be able to return in the allotted time.
Pedroia, 35, has played in six games with the Red Sox this season, going 2-for-20 with a run scored, an RBI and two strikeouts.
A four-time All-Star and the 2008 AL MVP, Pedroia underwent cartilage replacement surgery on his left knee after the 2017 season and played in only three games for the Red Sox last season before going back on the DL for the remainder of the season.